⚡ Stimulation

1 Hz (low-freq)
0.3
1.0x

🎮 Controls

📊 Statistics

Generation: 0
Synaptic Strength: 100%
AMPA Count: 0
Ca²⁺ Level: 0.00
Calcineurin: 0.00
PP1 Active: 0.00

📚 LTD Mechanism

Long-term depression is triggered by low-frequency stimulation causing modest calcium influx. This activates calcineurin (protein phosphatase 2B) which disinhibits PP1. PP1 then dephosphorylates AMPA receptors, triggering their internalization via clathrin-mediated endocytosis, weakening the synapse.