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Feedback Inhibition

Classic end-product inhibition: Isoleucine (the pathway end-product) allosterically inhibits threonine deaminase, the first enzyme committed to isoleucine synthesis.

Metabolite Levels:
Threonine 50
α-Ketobutyrate 30
Isoleucine 40
Enzyme Activity:
Thr Deaminase 60%
Inhibition: 40%
Homeostasis Score: 85%
Threonine (precursor)
α-Ketobutyrate (intermediate)
Isoleucine (end-product)
Threonine deaminase (IlvA)
Feedback inhibition signal