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Riboswitch Dynamics

RNA-based gene regulation: the mRNA itself can sense metabolites and switch between structures that permit or block translation. No protein factors needed!

ON State
Ribosome Access
OFF State
RBS Sequestered
RNA Conformation:
Permissive (ON)
Repressive (OFF)
Ligand Bound: 20%
Translation Rate: 80%
Proteins Made: 0
mRNA backbone
Aptamer domain
Expression platform
Ligand molecule
Ribosome