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RNA Interference

siRNA and miRNA silence genes by targeting mRNA for degradation or blocking translation. The RISC complex is the molecular machinery that executes silencing.

mRNA Levels:
Target mRNA
Silenced
Active RISC: 0
mRNAs Cleaved: 0
Translation Blocked: 0
Silencing Efficiency: 0%
siRNA/miRNA
RISC complex
Target mRNA
Cleaved/blocked mRNA
Protein product