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Action Potential
This simulation implements the Hodgkin-Huxley model of the action potential,
showing how voltage-gated sodium and potassium channels generate the all-or-none
electrical signal that propagates along neurons.
The Hodgkin-Huxley Equations
The membrane potential (V) changes according to:
Cm dV/dt = Istim - INa - IK - IL
where:
- INa = g̅Nam³h(V - ENa)
- IK = g̅Kn⁴(V - EK)
- IL = gL(V - EL)
Phases of the Action Potential
- Resting: V ≈ -65 mV, dominated by K⁺ leak
- Threshold: Depolarization to ~-55 mV triggers rapid Na⁺ channel opening
- Depolarization: Na⁺ rushes in, V approaches ENa (+55 mV)
- Repolarization: Na⁺ channels inactivate, K⁺ channels open
- Hyperpolarization: K⁺ outflow overshoots resting potential
- Refractory Period: Na⁺ channels recover from inactivation
All-or-None Response
Once threshold is reached, the action potential fires with full amplitude regardless
of stimulus strength. This is due to the positive feedback loop: depolarization
opens more Na⁺ channels, causing more depolarization.
Refractory Periods
- Absolute: Na⁺ channels inactivated, no AP possible
- Relative: Some Na⁺ channels recovered, stronger stimulus needed